The most common side effects of the drug include nausea, headache, dry mouth and sleepiness — but more serious side effects may occur. Like most antidepressants, Cymbalta (duloxetine) may trigger suicidal thoughts and behavior in children, adolescents and adults under the age of 24. According to the FDA (U.S Food & Drug Administration), there were 888 reports of adverse effects from duloxetine discontinuation in 2017, the highest number for any serotonin receptor-based antidepressant. In a 2005 study on generic duloxetine, it was found that 44 percent of users experienced withdrawal symptoms. The anti-depressant Cymbalta (duloxetine) can cause a host of side effects, but stopping the drug could also provoke unpleasant withdrawal symptoms. Six weeks later, I’m still having several side effects from Cymbalta, some of them from being on it and some of them are obviously part of the well-documented “Cymbalta Withdrawal Syndrome.” We have received so many complaints about duloxetine side effects that we have lost count. Far more disturbing are the number of people who tell us how hard it is to discontinue this drug. After a time on the market, duloxetine was approved for the off-label treatment of conditions like fibromyalgia, diabetic neuropathy, and chronic muscle and joint pain. Just how long the withdrawal effects lasted for those patients is unknown because Lilly never evaluated the effects of Cymbalta withdrawal beyond two weeks. This means patients and doctors have no idea just how long Cymbalta withdrawal could last. Hey there, good for you for trying to make the change after suffering those icky side effects. I understand! Because everyone is different the length of time it takes to get it out of your system will vary. So we're all talking about drugs, side effects and how it's altering our lives. How about some help on Natural Ways to combat Cymbalta and the withdrawal symptoms we feel.Please share. How about some help on Natural Ways to combat Cymbalta and the withdrawal symptoms we feel.Please share.